A Method for Patient-specific Assessment of Abdominal Aortic Aneurysm Rupture Risk Based on Geometric Biomechanics Factors. Clinical Validation Test
Última modificación: 2011-04-29 02:35
Resumen
Abdominal aortic aneurysms (AAAs) rupture is one of the main causes of death in the world. This is a very complex phenomenon that usually occurs “without previous warning”. Currently, criteria to assess the aneurysm rupture risk (peak diameter and growth rate) can not be considered as reliable indicators. In order to improve the predicting of AAA rupture risk, it had been developed a simple method, where the main geometric parameters of aneurysms have been linked into six biomechanical factors, which have been combined to obtain a dimensionless rupture risk index, RI(t). Based on the initial results of the validation tests of this method, a broader prospective randomised control study with two hundred and one patients at the Clinic Hospital of Valladolid-Spain using a new set of weighted coefficient values for each biomechanical factor, it has been carried out in this work. The outcomes of the present work shown that it is possible to implement a clinical assessment of the AAA rupture risk through its geometric parameters. The quantitative indicator defined is easy to understand, it allows estimating the aneurysms rupture risks, it is able to identify the ones that ruptures even when its peak diameter is less than the threshold value and also identifies those cases where the rupture should not occur regardless the maximum diameter is greater than the rupture threshold value and consequently avoids the patients to be submitted to surgical procedure. According to the results, the most relevant geometric biomechanical factors are the deformation rate, the growth rate. Beside these one, but less important, resulted the saccular index.