V Congreso Latinoamericano de Ingeniería Biomédica (CLAIB2011)

Influência da Região de Interesse nos Mapas de ADC Calculados por Ferramenta Computacional para Diagnóstico de Tumores Cerebrais in vivo
Tavares Costa Eduardo, Marina de Souza Edna, Castellano Gabriela

##manager.scheduler.building##: Palacio de Convenciones de La Habana
##manager.scheduler.room##: Sala 8
Fecha: 2011-05-20 12:45  – 01:00
Última modificación: 2011-04-28 05:02


In diffusion-weighted magnetic resonance imaging (DWI), the contrast is determined by the random microscopic motion of water protons. In general, pathologic processes, such as neoplasic cell changes, tend to alter the magnitude of structural organization by destruction or reorganization of membranous elements or by a change in cellularity. These changes also have an impact on proton mobility, which can be followed up by DWI. ADC (Apparent Diffusion Coefficient) map are derived from DWI being a representation of the magnitude of water diffusion at the points of a given region of interest (ROI). The purpose of this study was to develop a tool for computation of ADC maps to test the tool for ROI dependence of ADC values and apply this technique to the characterization of multiform glioblastoma. The mean ADC values found on glioblastoma images was (2.83±0,45)x10-4 mm2/s and on control images (8.65±0.98)x10-4 mm2/s allowing the differentiation between this type of tumor and healthy brain tissue. Important dependences of ADC values with ROI were not found in the ADC values for the control group in order to determine reference values for normal brain tissue.