Efeito do tempo de doença na biomecânica respirató Artrite Reumatóide
Última modificación: 2011-03-26 08:38
Resumen
Rheumatoid arthritis (RA) is a rheumatic disease
that primarily affects peripheral joints, but its mortality is
directly related to pulmonary involvement. Some results have
shown that spirometric exams are often normal in these
individuals. Recently, a prototype of an instrument
implementing the Forced Oscillation Technique (FOT) was
used in the analysis of these patients, showing significant
adverse modifications in biomechanics. This study evaluates
the effect of the duration of the disease on respiratory function
by spirometry and FOT. For this purpose, the study involved
11 normal subjects and 38 patients that were classified into
four groups according to disease duration. There was no
change in the values of spirometric parameters with disease
duration. On the other hand, the FOT resistive parameters R0
and Rm increased significantly (p<0.0001, p<0.00001), while
the dynamic compliance (Cdyn,rs) decreased significantly
(p<0.00001), with disease duration. The correlations confirm
these results, demonstrating r2
values of 0.11 for R0 and 0.24
for Cdyn,rs. We conclude that there are significant changes in
the biomechanical properties of the respiratory system of
individuals with RA that are associated with disease duration
and that this early changes may be detected by the FOT.
that primarily affects peripheral joints, but its mortality is
directly related to pulmonary involvement. Some results have
shown that spirometric exams are often normal in these
individuals. Recently, a prototype of an instrument
implementing the Forced Oscillation Technique (FOT) was
used in the analysis of these patients, showing significant
adverse modifications in biomechanics. This study evaluates
the effect of the duration of the disease on respiratory function
by spirometry and FOT. For this purpose, the study involved
11 normal subjects and 38 patients that were classified into
four groups according to disease duration. There was no
change in the values of spirometric parameters with disease
duration. On the other hand, the FOT resistive parameters R0
and Rm increased significantly (p<0.0001, p<0.00001), while
the dynamic compliance (Cdyn,rs) decreased significantly
(p<0.00001), with disease duration. The correlations confirm
these results, demonstrating r2
values of 0.11 for R0 and 0.24
for Cdyn,rs. We conclude that there are significant changes in
the biomechanical properties of the respiratory system of
individuals with RA that are associated with disease duration
and that this early changes may be detected by the FOT.