V Congreso Latinoamericano de Ingeniería Biomédica (CLAIB2011)

Development of a novel irradiator for the study of radiation effects at low dose rate in cell cultures
Batista Cancino Jorge Luis, Rodríguez Gual Maritza, Calderón Marín Carlos Fabian, González González Joaquín Jorge, Marrero Osorio Sergio, Wellesley Funcasta Jorge

Última modificación: 2011-03-22 04:22


In the present work the development of an in-house irradiator for irradiation at low dose rate (below to 1 cGy/min) is described. The knowledge about the biological effects of irradiation at low dose rate is limited. Otherwise the irradiation with beta particles will be also of interest as it´s happens in systemic radiotherapy; the biological effects of low dose could be also studied. The cell irradiator consists in an acrylic rectangular box with a capillar array where a solution of the radionuclide will be dispended inside. The MCNPX code was used for the calculation of the spatial doses profiles in the target (an slice of 3mm in depth of water). The absorbed dose rate for 1MBq of activity are 1.403mGy/h and 3.029mGy/h for P32 and Y90 respectively. The physical features of the irradiation field are appropiated with an useful area or useful irradiation field of about a 80% of total area occupied by the source.