V Congreso Latinoamericano de Ingeniería Biomédica (CLAIB2011)

Neurotrasplante de Células Guiado por Imágenes Multimodales
Carballo Barreda Maylen, Rodriguez Rojas Rafael, Sánchez Catasús Carlos, García Maeso Ivan

Fecha: 2011-05-19 09:30  – 09:45
Última modificación: 2011-04-15 05:59


Human stem cell transplantation is a novel treatment under active research to restore lost brain function following a stroke. In this work, we propose a multiparametric framework, based on multimodal image fusion, for stereotactic implantation of human stem cells in brain targets. Five patients underwent image-guided surgical procedure using this technique. Three dimensional T1-weighted and T2-weighted magnetic resonance imaging (MRI) were acquired for topographical and geometrical characterization of lesions. Affine registration of 3D-MRI and single-photon emission tomography (SPECT) is used to localize areas with preserved blood flow in the lesion boundaries, considered as the surgical target. Once it has been selected a single-voxel magnetic resonance spectroscopy (MRS) is developed to verify the tissue’s biochemical condition and for in-vivo follow up purposes. Pre-operative stereotactic computed tomography (CT) was performed for surgical planning. Frame-based computer assisted procedure was followed for targeting the implant site. All patients underwent uncomplicated surgeries. Post operative MRI showed high consistency between image-guided planning and transplantation site. Serial evaluations during 12 months demonstrated no surgery-related adverse effects. Multimodal coregistration offers a suitable approach for selection and stereotactic access of brain targets for human stem cell transplantation.