V Congreso Latinoamericano de Ingeniería Biomédica (CLAIB2011)

Criogeles de poli N-isopropilacrilamida cargados con nanopartículas de quitosana y bemiparina.
Peniche Aguero Hazel, Reyes Felisa, Rodríguez Gema, Aguilar Maria Rosa, Peniche Carlos, San Roman del Barrio Julio

Última modificación: 2011-04-14 09:31

Resumen


Chitosan/bemiparin spherical nanoparticles with
a diameter of 429 + 134 nm were obtained by a complex
coacervation technique. Bemiparin release in PBS from
nanoparticles at 37 ºC was followed by HPLC. During the
first 72 hours 28 % bemiparin was released. From then on
release became very slow, reaching 33 % in 21 days.
Poly N-isopropylacrylamide (p-NIPA) cryogels were
synthesized by free radical polymerization of NIPA under
freezing conditions, using N-N’-methylenebisacrylamide as
cross-linker. Cryogels were loaded with nanoparticles and
freeze-dried. They exhibited thermoresponsive behavior
swelling at 15 ºC, below the lower critical solution
temperature (LCST) of p-NIPA and de-swelling at 37 ºC,
above its LCST.