Cardiovascular diseases constitute one of  the major
reasons  of  death  with  high  prevalence  in  the  western
industrialized  societies.  Endothelial  dysfunction  plays  a
fundamental  role  in  physiopathological  mechanisms  and  it  is considered  a  syndrome with  systemic manifestations  associated with  cardiovascular  significant  morbidity  and  mortality.  The concept of endothelial dysfunction might spread up to the vessels that  irrigate  the vascular wall and even more,  the bony marrow and  the progenitor cells of endothelium. The aim of  this project is  the  implementation  of  an  integral  system  for  real-time processing of pressure, flow, vascular dimension, field of velocity profile  and  wall  shear  stress  simultaneously  (using  Doppler velocimetry,  computational  fluid  dynamics,  piezoelectric  and
strain  gauge  sensors),  in  order  to  assess  endothelial  function. This  system  will  constitute  the  gold  standard  of  an  immediate miniaturization (using bioMems), for evaluating the endothelium capability,  in  accordance  to  the  development  of  implantable sensors with capacity of acquisition of additional magnitudes of the whole system, as temperatures, PH and Nitric Oxide