One of the implant materials that has aroused most interest in our country because of its high biocompatibility and osteoconductive nature is hydroxyapatite and in particular, the obtained from marine coral. In addition, to the advantages of hydroxyapatite could be added other properties if you combine this with a polymeric substance capable to release different biomolecules in a controlled manner. The aim of this work was to study the kinetics of protein release from a composite (HAP-200, CaCO3 and POVIAc(R)). The in vitro release study was performed in phosphate buffer. Five mathematical models were evaluated to describe the phenomenon of protein release from the composite studied. This model takes into consideration the contribution of the diffusion mechanism and the relaxation of polymeric chain mechanism. The 60.10% of protein was released in the first eight hours in contact with the medium. Of the five mathematical models studied, the equation proposed by Peppas and Sahlin was the one that best mathematical fit provide to the release profile of protein. There was a main contribution of the diffusion mechanism and a minor contribution of relaxation polymeric chain mechanism.