V Congreso Latinoamericano de Ingeniería Biomédica (CLAIB2011)

Estimulação elétrica para reversão da cardiodepressão na preparação de langendorff em circuito fechado
José Gustavo Tavares Padrão, Neto Afonso Caricati, Samuel Cukierman, de Godoy Carlos Marcelo Gurjão

Última modificación: 2011-04-13 09:12


It has been showed, in Langendorff preparation of rat hearts, that the depression of cardiac parameters were importantly mediated by substances released by the own heart in the perfusate (low volume- 100 ml; closed circulation).  In this study we tested if electric stimulation (ES) would reverse such a cardiac depression. Three physiological parameters of rat isolated hearts were quantified: cardiac frequency, left ventricular pressure and cardiac perfusion flow. The results showed that it is possible to partially reverse cardiac depressing functionality by renewing perfusate while using 10 min of cardiac arrest by ES. However, ES alone is not enough to prevent the decay on cardiac parameters.