V Congreso Latinoamericano de Ingeniería Biomédica (CLAIB2011)

The dynamic of electroporation in dilute cell suspension: a numerical and experimental study
Marques Luiz Brum Jefferson, Suzuki Ota Hisayasu Daniela, Ramos R Airton, Silva Regina Mena Barreto Fátima, Cazarolli Helena Luisa

##manager.scheduler.building##: Palacio de Convenciones de La Habana
##manager.scheduler.room##: Sala 5
Fecha: 2011-05-20 01:15  – 01:30
Última modificación: 2011-05-03 03:57


The electroporation is utilized in the gene therapy, DNA vaccination protocols, cancer treatment and introduce substances into cells. Nowadays, the experimental results are not completely understood and explained by a theory or mathematical model. This work proposed the compatibility between experimental and numerical results. The assymptotic model presented error less than 1%. The simulation provides information about the alteration of transmembrane potential and membrane conductance during electroporation pulse. The simulation of rest potential effect does not cause the electroporation asymmetry described experimentally.